{4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester
• CAS No.: 197971-38-3
• Molecular Formula: C₂₃H₃₀N₂O₅
• Molecular Weight: 414.502

Synonyms:{4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester

Chemical Property of {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester

There total 4 articles about {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester (197971-54-3) → {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester (197971-38-3)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1021/jm970414b

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester (197971-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

2: 81 percent / TBAF, AcOH / tetrahydrofuran / 6 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm970414b

Reference yield:

N1-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-butane-1,4-diamine → {4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester (197971-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

2: 81 percent / TBAF, AcOH / tetrahydrofuran / 6 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm970414b

upstream raw materials:

(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

benzyl chloroformate

Downstream raw materials:

(4-{Benzyloxycarbonyl-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-amino}-butyl)-carbamic acid benzyl ester

(S)-4-{(S)-1-[(Benzyloxy-{3-[benzyloxycarbonyl-(4-benzyloxycarbonylamino-butyl)-amino]-propoxy}-phosphorylmethyl)-carbamoyl]-ethylcarbamoyl}-2-benzyloxycarbonylamino-butyric acid benzyl ester

C₃₃H₃₉N₄O₈P

{4-[(3-amino-propyl)-benzyloxycarbonyl-amino]-butyl}-carbamic acid benzyl ester

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