benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

Base Information

Chemical Name:benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate
CAS No.:1159183-24-0
Molecular Formula:C₃₂H₂₇F₂NO₅
Molecular Weight:543.567
Hs Code.:

Synonyms:benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

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Chemical Property of benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

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Technology Process of benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

There total 3 articles about benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
ezetemibe

: 1159183-24-0
benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/acs.orglett.5b02522

Reference yield:

: 1159183-23-9
C₃₂H₂₅F₂NO₅

: 1159183-24-0
benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

: 191330-56-0
[14C]-Sch 57871

: 163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
ezetemibe

Guidance literature:: With D-glucose; at 30 ℃; for 24h; pH=7; diastereoselective reaction; Microbiological reaction; aq. phosphate buffer;
DOI:10.1016/j.molcatb.2010.09.006

Reference yield:

: 1159183-23-9
C₃₂H₂₅F₂NO₅

: 1159183-24-0
benzyl (4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl) carbonate

Guidance literature:: C₃₂H₂₅F₂NO₅; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -25 ℃; for 0.25h;

With dimethylsulfide borane complex; In tetrahydrofuran; at -25 - -20 ℃; for 2h;

With methanol; In tetrahydrofuran; at -25 - -20 ℃; for 0.25h; Product distribution / selectivity;