Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester

Base Information

• Chemical Name: Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester
• CAS No.: 108517-79-9
• Molecular Formula: C₃₇H₃₉N₃O₇S
• Molecular Weight: 669.799
• Mol file: 108517-79-9.mol

Synonyms:Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester

Chemical Property of Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester

There total 1 articles about Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

S-benzyl-N-[(benzyloxy)carbonyl]cysteinyltyrosine (39621-64-2) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester (108517-79-9)

Guidance literature:

With calcium chloride; thermolysin; In N,N-dimethyl-formamide; at 38 ℃; for 24h; pH 7.0;

Reference yield: 74.0%

Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester (108517-79-9) → Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine (108607-50-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 3h; Ambient temperature;

Reference yield:

Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine methyl ester (108517-79-9) → pressinoic acid (disulfide) (35748-51-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / 1 M NaOH / dioxane / 3 h / Ambient temperature

2: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7

3: 59 percent / ferric chloride / dimethylformamide; H₂O / 0.5 h / 35 °C

4: 1.) Na/NH₃, 2.) NH₄Cl, 3.) trifluoroacetic acid, O₂

With sodium hydroxide; ammonia; oxygen; sodium; iron(III) chloride; ammonium chloride; trifluoroacetic acid; α-chymotrypsin; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

S-benzyl-N-[(benzyloxy)carbonyl]cysteinyltyrosine

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanine

pressinoic acid (disulfide)

Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine

Benzyloxycarbonyl-S-benzylcysteinyl-tyrosyl-phenylalanyl-glutaminyl-asparaginyl-S-benzylcysteine phenylhydrazide