ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

Base Information

Chemical Name:ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate
CAS No.:1309436-19-8
Molecular Formula:C₃₃H₃₅NO₃S
Molecular Weight:525.712
Hs Code.:

Synonyms:ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

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Chemical Property of ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

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Technology Process of ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

There total 6 articles about ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1292290-97-1
(S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester

: 1309436-02-9
[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methanol

: 1309436-19-8
ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: [5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methanol; With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 ℃; for 0.25h;

(S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield:

: 137730-67-7
spiro(1H-indene-1,4'-piperidine) hydrochloride

: 1309436-19-8
ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.5 h / 30 °C / Inert atmosphere

1.2: 1.92 h / 30 - 60 °C

2.1: diisobutylaluminium hydride / dichloromethane / 7 h / -78 - 30 °C / Inert atmosphere

2.2: -78 °C

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 20 °C

With tributylphosphine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 108499-32-7
5-bromomethyl-2-carbomethoxythiophene

: 1309436-19-8
ethyl (3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-2-thienyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine / ethanol / 16 h / 20 - 90 °C

2.1: diisobutylaluminium hydride / dichloromethane / 7 h / -78 - 30 °C / Inert atmosphere

2.2: -78 °C

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 20 °C

With tributylphosphine; diisobutylaluminium hydride; diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; dichloromethane;