(3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester

Base Information

Chemical Name:(3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester
CAS No.:1292290-97-1
Molecular Formula:C14H16O3
Molecular Weight:232.279
Hs Code.:
Mol file:1292290-97-1.mol

Synonyms:(3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester;ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate;(S)-Ethyl 3-(4-hydroxyphenyl)hex-4-ynoate;(S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester;Benzenepropanoic acid, 4-hydroxy-β-1-propyn-1-yl-, ethyl ester, (βS)-;ethyl(S)-3-(4-hydroxyphenyl)hex-4-ynoate

Suppliers and Price of (3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-3-(4-Hydroxyphenyl)-4-hexynoicAcidEthylEster
50mg
$ 50.00

SynQuest Laboratories
Ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate 97.0%
250 mg
$ 490.00

SynQuest Laboratories
Ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate 97.0%
5 g
$ 2100.00

SynQuest Laboratories
Ethyl (3S)-3-(4-hydroxyphenyl)hex-4-ynoate 97.0%
1 g
$ 1390.00

Matrix Scientific
(3S)-3-(4-Hydroxyphenyl)-4-hexynoicacidethylester 97.0%
1g
$ 1073.00

Crysdot
(S)-Ethyl3-(4-hydroxyphenyl)hex-4-ynoate 95+%
10g
$ 2160.00

Crysdot
(S)-Ethyl3-(4-hydroxyphenyl)hex-4-ynoate 95+%
25g
$ 4320.00

Crysdot
(S)-Ethyl3-(4-hydroxyphenyl)hex-4-ynoate 95+%
5g
$ 1290.00

Crysdot
(S)-Ethyl3-(4-hydroxyphenyl)hex-4-ynoate 95+%
1g
$ 435.00

Chemenu
ethyl(3S)-3-(4-hydroxyphenyl)hex-4-ynoate 95+%
1g
$ 240.00

Total 11 raw suppliers

Chemical Property of (3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester

Chemical Property:

Boiling Point:369.0±37.0 °C(Predicted)
PKA:9.72±0.26(Predicted)
PSA：46.53000
Density:1.120±0.06 g/cm3(Predicted)
LogP:2.45230

Purity/Quality:

99%, ^*data from raw suppliers

(S)-3-(4-Hydroxyphenyl)-4-hexynoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (S)-3-(4-Hydroxyphenyl)-4-hexynoic Acid Ethyl Ester is a reagent in the synthesis of AMG 837 which is a GPR40 agonist used as antidiabetic agents.

Technology Process of (3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester

There total 12 articles about (3S)-3-(4-Hydroxyphenyl)-4-hexynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 865233-35-8
(3S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid

: 64-17-5
ethanol

: 1292290-97-1
(S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester

Guidance literature:: With sulfuric acid; at 20 ℃; for 6h; Inert atmosphere; Reflux;

Reference yield:

: C₁₆H₂₁BrO₄

: 74-99-7
prop-1-yne

: 1292290-97-1
(S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester

: 7361-92-4,7362-39-2,2979-06-8
ethyl 3-(4-hydroxyphenyl)prop-2-enoate

Guidance literature:: C₁₆H₂₁BrO₄; prop-1-yne; With copper(I) thiophene-2-carboxylate; C₅₄H₆₈N₃OP; caesium carbonate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 72h; Inert atmosphere; Schlenk technique;

With ethanol; potassium carbonate; at 20 ℃; for 4h; enantioselective reaction;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1292290-97-1
(S)-3-(4-hydroxy-phenyl)-hex-4-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 2 h / 75 °C

2.1: tetrahydrofuran / 0.25 h / 50 °C / Inert atmosphere

3.1: pyridine; water / 16 h / Reflux

3.2: pH ~ 2

4.1: trifluoroacetic acid / isopropyl alcohol; hexane / Resolution of racemate

5.1: sulfuric acid / 4 h / Reflux

With pyridine; sulfuric acid; water; trifluoroacetic acid; In tetrahydrofuran; hexane; water; isopropyl alcohol;