tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Base Information

• Chemical Name: tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate
• CAS No.: 1391597-35-5
• Molecular Formula: C₂₃H₃₁NO₄
• Molecular Weight: 385.503
• Mol file: 1391597-35-5.mol

Synonyms:tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Chemical Property of tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate

There total 2 articles about tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 2-methylpropanoate (16889-72-8) + N-(4-methoxybenzylidene)-2-methoxybenzenamine (1624-51-7,57420-67-4) → tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate (1391597-35-5)

Guidance literature:

With potassium hydride; In tert-butyl methyl ether; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c2ob25522g

Reference yield:

2-methoxy-phenylamine (90-04-0) + 4-methoxy-benzaldehyde (123-11-5) → tert-butyl 3-(4-methoxyphenyl)-3-((2-methoxyphenyl)amino)-2,2-dimethylpropanoate (1391597-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Molecular sieve

2: potassium hydride / tert-butyl methyl ether / 12 h / 20 °C / Inert atmosphere

With potassium hydride; In tert-butyl methyl ether; 2: Mannich reaction;

DOI:10.1039/c2ob25522g

upstream raw materials:

tert-butyl 2-methylpropanoate

N-(4-methoxybenzylidene)-2-methoxybenzenamine

2-methoxy-phenylamine

4-methoxy-benzaldehyde