cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

Base Information

Chemical Name:cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide
CAS No.:1343461-33-5
Molecular Formula:C₂₅H₃₀FN₃O₄S
Molecular Weight:487.595
Hs Code.:

Synonyms:cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

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Chemical Property of cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

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Technology Process of cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

There total 7 articles about cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 154350-29-5
cyclopropanesulphonamide

: 1343461-44-8
8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid

: 1343461-33-5
cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

Guidance literature:: cyclopropanesulphonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 1h;

8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

Reference yield:

: 1343461-39-1
2-(3-bromo-phenyl)-8-fluoro-4-hydroxy-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid methyl ester

: 1343461-33-5
cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C

2.1: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

4.2: 1 h / 25 °C

With triethylsilane; water; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium hydroxide; copper(l) iodide; N,N-dimethylglycine hydrochoride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Ullmann Reaction;

Reference yield:

: 1343461-40-4
2-(3-bromo-phenyl)-8-fluoro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid methyl ester

: 1343461-33-5
cyclopropanesulfonic acid [8-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3.2: 1 h / 25 °C

With water; sodium hydride; potassium carbonate; sodium hydroxide; copper(l) iodide; N,N-dimethylglycine hydrochoride; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 1.1: Ullmann Reaction;