3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester
• CAS No.: 93663-71-9
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Hs Code.: 2933499090
• Mol file: 93663-71-9.mol

Synonyms:3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester

Chemical Property of 3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester

Chemical Property:

• Vapor Pressure: 5.41E-10mmHg at 25°C
• Boiling Point: 496.4°C at 760 mmHg
• Flash Point: 254°C
• PSA: 68.39000
• Density: 1.241g/cm³
• LogP: 3.38040

Purity/Quality:

3-QUINOLINECARBOXYLIC ACID, 4-HYDROXY-6-METHOXY-2-PHENYL-, ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester

There total 8 articles about 3-Quinolinecarboxylic acid, 4-hydroxy-6-methoxy-2-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-[(4-methoxy-phenylamino)-phenyl-methylene]-malonic acid diethyl ester (828264-17-1) → ethyl 6-methoxy-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate (93663-71-9,828264-32-0)

Guidance literature:

In diphenylether; at 230 - 250 ℃; for 1h;

DOI:10.1016/j.ejmech.2005.03.008

Reference yield: 59.0%

→ ethyl 6-methoxy-4-oxo-2-phenyl-1,4-dihydroquinoline-3-carboxylate (93663-71-9,828264-32-0)

Guidance literature:

Reference yield:

sodium diethylmalonate (996-82-7) + N-(4-methoxyphenyl)benzimidoyl chloride (34918-74-6) → 4-hydroxy-6-methoxy-2-phenyl-quinoline-3-carboxylic acid ethyl ester (93663-71-9)

Guidance literature:

With toluene; Erhitzen des Reaktionsprodukts bis auf 170grad;

DOI:10.1021/ja01211a042

upstream raw materials:

sodium diethylmalonate

N-(4-methoxyphenyl)benzimidoyl chloride

2-[(4-methoxy-phenylamino)-phenyl-methylene]-malonic acid diethyl ester

ethyl 3-chloro-2-(ethoxycarbonyl)-3-phenyl-propenoate

Downstream raw materials:

4-chloro-6-methoxy-2-phenylquinoline

ethyl 4-(3-acetylanilino)-6-methoxy-2-phenyl-quinoline-3-carboxylate

ethyl 4-(4-acetylanilino)-6-methoxy-2-phenyl-quinoline-3-carboxylate

4-(4-acetyl-phenylamino)-6-methoxy-2-phenyl-quinoline-3-carboxylic acid