4-Chloro-6-methoxy-2-phenylquinoline

Base Information

• Chemical Name: 4-Chloro-6-methoxy-2-phenylquinoline
• CAS No.: 50593-72-1
• Molecular Formula: C16H12 Cl N O
• Molecular Weight: 269.73
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID20353161
• Wikidata: Q82130622
• Mol file: 50593-72-1.mol

Synonyms:4-chloro-6-methoxy-2-phenylquinoline;50593-72-1;Oprea1_364366;SCHEMBL6534209;DTXSID20353161;JUDKYVTYOZVODY-UHFFFAOYSA-N;MFCD00023968;AKOS002673952;4-chloro-6-methoxy-2-phenyl-quinoline;AE-562/12222923

Chemical Property of 4-Chloro-6-methoxy-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.08E-06mmHg at 25°C
• Melting Point: 121 °C
• Boiling Point: 414.3°C at 760 mmHg
• Flash Point: 204.4°C
• PSA: 22.12000
• Density: 1.237g/cm³
• LogP: 4.56380
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 269.0607417
• Heavy Atom Count: 19
• Complexity: 293

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-6-METHOXY-2-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(C=C2Cl)C3=CC=CC=C3

Technology Process of 4-Chloro-6-methoxy-2-phenylquinoline

There total 19 articles about 4-Chloro-6-methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-methoxy-2-phenyl-1H-quinolin-4-one (57183-50-3) → 4-chloro-6-methoxy-2-phenylquinoline (50593-72-1)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1016/j.ejmech.2005.03.008

Reference yield: 89.0%

6-methoxy-2-phenylquinolin-4-ol (17282-70-1) → 4-chloro-6-methoxy-2-phenylquinoline (50593-72-1)

Guidance literature:

With trichlorophosphate; at 110 ℃;

DOI:10.1016/j.ejmech.2019.111649

Reference yield:

6-methoxy-2-phenylquinoline-N-oxide (61845-41-8) → 4-chloro-6-methoxy-2-phenylquinoline (50593-72-1)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01232a034

upstream raw materials:

4-chloro-6-methoxyquinoline

phenyllithium

6-methoxy-2-phenylquinolin-4-ol

6-methoxy-2-phenylquinoline-N-oxide

Downstream raw materials:

N⁴,N⁴-diethyl-N¹-(6-methoxy-2-phenyl-[4]quinolyl)-1-methyl-butanediyldiamine

1-[3-(6-methoxy-2-phenyl-quinolin-4-ylamino)-phenyl]-ethanone

4-(4-acetyl phenyl amino)-6-methoxy-2-phenylquinoline

4-chloro-2-phenyl-quinolin-6-ol