2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

Base Information

Chemical Name:2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol
CAS No.:1433948-18-5
Molecular Formula:C₂₀H₂₃ClFNO₂
Molecular Weight:363.86
Hs Code.:

Synonyms:2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

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Chemical Property of 2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

Chemical Property:

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Technology Process of 2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

There total 7 articles about 2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433407-79-4
[3-(1-bromopropyl)-6-chloro-2-fluorophenyl]phenylmethanone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1433948-18-5
2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 261762-82-7
6-chloro-2-fluoro-3-methylbenzoyl chloride

: 1433948-18-5
2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributylphosphine / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

1.2: 0.75 h

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

6.1: N,N-dimethyl-formamide / 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tributylphosphine; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1433409-07-4
(6-chloro-2-fluoro-3-methylphenyl)phenylmethanone

: 1433948-18-5
2-{[1-(3-benzoyl-4-chloro-2-fluorophenyl)propyl]amino}-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 22 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 80 °C

3: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 20 °C

5: N,N-dimethyl-formamide / 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;