7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
CAS No.:1315513-52-0
Molecular Formula:C₂₆H₃₄ClN₇O₄
Molecular Weight:544.053
Hs Code.:

7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Synonyms:7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Chemical Property of 7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

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Technology Process of 7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

There total 9 articles about 7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 7-amino-8-(2-hydroxy-2-methylpropyl)-2-[2-methoxy-4-(piperid-4-yl)phenylamino]-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide dihydrochloride

: 107-06-2,52399-93-6
1,2-dichloro-ethane

: 1315513-52-0
7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: With methoxyacetaldehyde; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 2h;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1315513-52-0
7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 20 °C

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C / 2250.23 Torr / Autoclave

4: 2 h / 110 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C / Cooling with ice

6: N-ethyl-N,N-diisopropylamine; methoxyacetaldehyde; sodium tris(acetoxy)borohydride / 2 h / 20 °C

With hydrogenchloride; methanol; methoxyacetaldehyde; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 103966-66-1
4-bromo-2-methoxy-1-nitro-benzene

: 1315513-52-0
7-amino-2-{4-[1-(2-chloroethyl)piperid-4-yl]-2-methoxyphenylamino}-8-(2-hydroxy-2-methylpropyl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C / 2250.23 Torr / Autoclave

3: 2 h / 110 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C / Cooling with ice

5: N-ethyl-N,N-diisopropylamine; methoxyacetaldehyde; sodium tris(acetoxy)borohydride / 2 h / 20 °C

With hydrogenchloride; methoxyacetaldehyde; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;