(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Chemical Name:(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate
CAS No.:1314607-35-6
Molecular Formula:C₄₀H₄₇F₃N₁₄O₁₁
Molecular Weight:956.896
Hs Code.:

(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Synonyms:(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Chemical Property of (S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Technology Process of (S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

There total 6 articles about (S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: (S)-methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-((tert-butoxycarbonyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate dihydrochloride

: 1046806-28-3
N²,N,N-dimethylaminomethylene-10-formyl-pteroic acid

: 1314607-35-6
(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: (S)-methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-((tert-butoxycarbonyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate dihydrochloride; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 0 ℃; for 15h; Inert atmosphere;

N²,N,N-dimethylaminomethylene-10-formyl-pteroic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; for 42h; Inert atmosphere;

Reference yield:

: 69173-92-8
4-azido-1-nitro-2,3,5,6-tetrafluorobenzene

: 1314607-35-6
(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 60 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

5.2: 42 h / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1314607-31-2
tert-butyl [3-(2-{2-[3-(3-azido-2,4,5-trifluoro-6-nitrophenylamino)propoxy]ethoxy}ethoxy)propyl]carbamate

: 1314607-35-6
(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

4.2: 42 h / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;