2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid

Base Information

• Chemical Name: 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid
• CAS No.: 1574531-76-2
• Molecular Formula: C₂₁H₂₁N₃O₃
• Molecular Weight: 363.416
• Mol file: 1574531-76-2.mol

Synonyms:2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid

Chemical Property of 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid

There total 4 articles about 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester (1574531-73-9) → 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid (1574531-76-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 72h;

DOI:10.1021/ic402695c

Reference yield:

3,4-dimethylanisole (4685-47-6) → 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid (1574531-76-2)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(ll) sulfate pentahydrate; dipotassium peroxodisulfate; aminosulfonic acid; sodium chlorite

2: sulfuric acid

3: N-Bromosuccinimide; dibenzoyl peroxide

4: triethylamine / tetrahydrofuran / 7 h / Reflux

5: sodium hydroxide / methanol; water / 72 h / 20 °C

With sodium chlorite; dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; sulfuric acid; aminosulfonic acid; triethylamine; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; water;

DOI:10.1021/ic402695c

Reference yield:

4-methoxy-2-methylbenzoic acid (6245-57-4) → 2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid (1574531-76-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid

2: N-Bromosuccinimide; dibenzoyl peroxide

3: triethylamine / tetrahydrofuran / 7 h / Reflux

4: sodium hydroxide / methanol; water / 72 h / 20 °C

With N-Bromosuccinimide; sulfuric acid; triethylamine; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; water;

DOI:10.1021/ic402695c

upstream raw materials:

2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester

3,4-dimethylanisole

4-methoxy-2-methylbenzoic acid

methyl 4-methoxy-2-methylbenzoate