2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester

Base Information

• Chemical Name: 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester
• CAS No.: 1574531-73-9
• Molecular Formula: C₂₂H₂₃N₃O₃
• Molecular Weight: 377.443
• Mol file: 1574531-73-9.mol

Synonyms:2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester

Chemical Property of 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester

There total 4 articles about 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-(bromomethyl)-4-(methyloxy)benzoate (15365-25-0) + bis[(2-pyridyl)methyl]amine (1539-42-0) → 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester (1574531-73-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 7h; Reflux;

DOI:10.1021/ic402695c

Reference yield:

4-methoxy-2-methylbenzoic acid (6245-57-4) → 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester (1574531-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid

2: N-Bromosuccinimide; dibenzoyl peroxide

3: triethylamine / tetrahydrofuran / 7 h / Reflux

With N-Bromosuccinimide; sulfuric acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran;

DOI:10.1021/ic402695c

Reference yield:

3,4-dimethylanisole (4685-47-6) → 2-[(bis-pyridin-2-ylmethylamino)methyl]-4-methoxybenzoic acid methyl ester (1574531-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(ll) sulfate pentahydrate; dipotassium peroxodisulfate; aminosulfonic acid; sodium chlorite

2: sulfuric acid

3: N-Bromosuccinimide; dibenzoyl peroxide

4: triethylamine / tetrahydrofuran / 7 h / Reflux

With sodium chlorite; dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; sulfuric acid; aminosulfonic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran;

DOI:10.1021/ic402695c

upstream raw materials:

methyl 2-(bromomethyl)-4-(methyloxy)benzoate

bis[(2-pyridyl)methyl]amine

3,4-dimethylanisole

4-methoxy-2-methylbenzoic acid

Downstream raw materials:

2-{[bis(pyridine-2-ylmethyl)-amino]methyl}-4-methoxy benzoic acid

Refernces