tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

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Chemical Name:tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate
CAS No.:1239964-53-4
Molecular Formula:C₃₁H₃₀ClF₃N₂O₃S
Molecular Weight:603.105
Hs Code.:

Synonyms:tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

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Chemical Property of tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

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Technology Process of tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

There total 15 articles about tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1239964-18-1
tert-butyl 3,5-difluoro-4-[(methanesulfonyloxy)methyl]benzoate

: 1239963-85-9
5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

: 1239964-53-4
tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

Guidance literature:: With caesium carbonate; In acetonitrile; for 2h;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239964-53-4
tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

7: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8: acetic acid / 4 h / Reflux

9: caesium carbonate / acetonitrile / 2 h

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; sulfuric acid; hydrogen; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239964-53-4
tert-butyl 4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difiuorobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / 4 h / Reflux

7: caesium carbonate / acetonitrile / 2 h

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; hydrogen; caesium carbonate; acetic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;