[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Base Information

Chemical Name:[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate
CAS No.:1247008-25-8
Molecular Formula:C₃₄H₃₈N₂O₈
Molecular Weight:602.684
Hs Code.:

[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Synonyms:[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Chemical Property of [1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Technology Process of [1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

There total 10 articles about [1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1247008-23-6
2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

: 80841-78-7
4-chloromethyl-5-methyl-1,3-dioxol-2-one

: 1247008-25-8
[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 79443-97-3
methyl 2-(4-methylphenyl)propanoate

: 1247008-25-8
[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / hexane / 24 h / 20 °C / Inert atmosphere

2: dibenzoyl peroxide; N-Bromosuccinimide / dichloromethane / 12 h / Reflux

3: potassium carbonate / acetone / 24 h / Reflux

4: sodium hydroxide / methanol / 12 h / Reflux

5: potassium carbonate / N,N-dimethyl acetamide / 12 h / 20 °C

With N-Bromosuccinimide; sodium hydride; potassium carbonate; sodium hydroxide; dibenzoyl peroxide; In methanol; hexane; dichloromethane; N,N-dimethyl acetamide; acetone;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-25-8
[1-[[4-[1,1-dimethyl-2-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]-2-oxoethyl]phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / acetic acid; methanol / 48 h / 20 °C / 3750.38 Torr

2: potassium carbonate / acetone / 24 h / Reflux

3: sodium hydroxide / methanol / 12 h / Reflux

4: potassium carbonate / N,N-dimethyl acetamide / 12 h / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl acetamide; acetic acid; acetone;
DOI:10.1016/j.ejmech.2013.03.060