2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

Base Information

Chemical Name:2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid
CAS No.:1247008-23-6
Molecular Formula:C₂₉H₃₄N₂O₅
Molecular Weight:490.599
Hs Code.:

Synonyms:2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

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Chemical Property of 2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

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Technology Process of 2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

There total 9 articles about 2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1247008-47-4
[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-23-6
2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 12h; Reflux;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-23-6
2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / acetic acid; methanol / 48 h / 20 °C / 3750.38 Torr

2: potassium carbonate / acetone / 24 h / Reflux

3: sodium hydroxide / methanol / 12 h / Reflux

With palladium on activated charcoal; hydrogen; potassium carbonate; sodium hydroxide; In methanol; acetic acid; acetone;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 938-94-3
(R,S)-2-(4'-methylphenyl) propionic acid

: 1247008-23-6
2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2: sodium hydride / hexane / 24 h / 20 °C / Inert atmosphere

3: dibenzoyl peroxide; N-Bromosuccinimide / dichloromethane / 12 h / Reflux

4: potassium carbonate / acetone / 24 h / Reflux

5: sodium hydroxide / methanol / 12 h / Reflux

With N-Bromosuccinimide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; dibenzoyl peroxide; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.03.060