(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Base Information

Chemical Name:(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate
CAS No.:152811-81-9
Molecular Formula:C₂₅H₂₈N₂O₃
Molecular Weight:404.509
Hs Code.:

Synonyms:(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Chemical Property of (1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

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Technology Process of (1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

There total 1 articles about (1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 67686-01-5
1-benzyl-4-piperidinemethanol

: 203585-25-5
methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: 1-benzyl-4-piperidinemethanol; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-47-4
[1-[[4-(2-methoxy-1,1-dimethyl-2-oxoethyl)phenyl]methyl]-4-piperidinyl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / acetic acid; methanol / 48 h / 20 °C / 3750.38 Torr

2: potassium carbonate / acetone / 24 h / Reflux

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; acetic acid; acetone;
DOI:10.1016/j.ejmech.2013.03.060

Reference yield:

: 152811-81-9
(1-benzyl-4-piperidinyl)methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

: 1247008-23-6
2-[4-[[4-(3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)-1-piperidinyl]methyl]phenyl]-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / acetic acid; methanol / 48 h / 20 °C / 3750.38 Torr

2: potassium carbonate / acetone / 24 h / Reflux

3: sodium hydroxide / methanol / 12 h / Reflux

With palladium on activated charcoal; hydrogen; potassium carbonate; sodium hydroxide; In methanol; acetic acid; acetone;
DOI:10.1016/j.ejmech.2013.03.060