(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

Base Information

Chemical Name:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone
CAS No.:1445985-69-2
Molecular Formula:C₂₆H₃₀Cl₂N₂O₃
Molecular Weight:489.442
Hs Code.:

Synonyms:(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

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Chemical Property of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

Chemical Property:

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Technology Process of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

There total 14 articles about (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1445985-68-1
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybut-1-ynyl)phenoxy)methyl)cyclopropyl)methanone

: 1445985-69-2
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

Guidance literature:: With rhodium contaminated with carbon; hydrogen; In ethyl acetate;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-69-2
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 10 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

6: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C

7: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

8: potassium carbonate / acetone / 55 °C

9: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

10: rhodium contaminated with carbon; hydrogen / ethyl acetate

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; borane-THF; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-69-2
(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybutyl)phenoxy)methyl)cyclopropyl)methanone

Guidance literature:: Multi-step reaction with 9 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C

6: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

7: potassium carbonate / acetone / 55 °C

8: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

9: rhodium contaminated with carbon; hydrogen / ethyl acetate

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; borane-THF; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;