methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Base Information

• Chemical Name: methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate
• CAS No.: 1345870-51-0
• Molecular Formula: C₂₄H₁₈Cl₂N₂O₃S
• Molecular Weight: 485.391

Synonyms:methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Chemical Property of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Chemical Property:

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Technology Process of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

There total 2 articles about methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-33-8) → methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-51-0)

Guidance literature:

With Lawessons reagent; In toluene; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.09.043

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) + 1-isocyanocyclohexene (1121-57-9) + dl-α-4-chlorophenylglycine methyl ester hydrochloride (42718-19-4,59410-89-8) → methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C

1.2: 0 - 20 °C

1.3: 45 - 70 °C

2.1: Lawessons reagent / toluene / 4 h / 70 °C / Inert atmosphere

With Lawessons reagent; potassium hydroxide; In methanol; toluene; 1.2: Ugi four component condensation;

DOI:10.1016/j.ejmech.2011.09.043

upstream raw materials:

methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

ortho-nitrobenzoic acid

1-isocyanocyclohexene

dl-α-4-chlorophenylglycine methyl ester hydrochloride

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