1121-57-9Relevant articles and documents
The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.
Rosalba, Thaissa Pasquali F.,Kas, Samia Sayegh A.,Sampaio, Ana Beatriz S.,Salvador, Carlos Eduardo M.,Andrade, Carlos Kleber Z.
, p. 2831 - 2842 (2021/05/13)
Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.
A general simple methodology for synthesis of isonitriles using benzene-1,3-disulfonyl dichloride
Ghorbani-Vaghei, Ramin,Amiri, Mostafa,Veisi, Hojat
, p. 37 - 41 (2013/07/26)
Isonitrile derivatives have been synthesized in good to high yields by dehydration of aliphatic and aromatic formamides in the presence of benzene-1,3-disulfonyl dichloride as easy and efficient reagent.
Synthetic studies toward lapidilectine-type Kopsia alkaloids
Schultz, Erica E.,Pujanauski, Brian G.,Sarpong, Richmond
supporting information; experimental part, p. 648 - 651 (2012/03/08)
A rapid synthesis of the tetracyclic core of Kopsia indole alkaloids related to lapidilectine B, grandilodine C, and tenuisine A is reported. Key to the success of this route was an efficient and scalable Ugi four-component coupling to install all the necessary carbons found in the natural products.
