methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Base Information

• Chemical Name: methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate
• CAS No.: 1345870-33-8
• Molecular Formula: C₂₄H₁₈Cl₂N₂O₄
• Molecular Weight: 469.324
• Mol file: 1345870-33-8.mol

Synonyms:methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Chemical Property of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate

There total 1 articles about methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

methanol (67-56-1) + ortho-nitrobenzoic acid (552-16-9,104810-18-6) + 1-isocyanocyclohexene (1121-57-9) + 4-chlorobenzaldehyde (104-88-1) + dl-α-4-chlorophenylglycine methyl ester hydrochloride (42718-19-4,59410-89-8) → methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-33-8)

Guidance literature:

ortho-nitrobenzoic acid; With potassium hydroxide; In methanol; at 20 ℃; for 0.166667h;

methanol; 1-isocyanocyclohexene; 4-chlorobenzaldehyde; dl-α-4-chlorophenylglycine methyl ester hydrochloride; at 0 - 20 ℃;

With iron; acetic acid; at 45 - 70 ℃;

DOI:10.1016/j.ejmech.2011.09.043

Reference yield: 78.3%

methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-33-8) → methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate (1345870-51-0)

Guidance literature:

With Lawessons reagent; In toluene; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.09.043

upstream raw materials:

methanol

ortho-nitrobenzoic acid

1-isocyanocyclohexene

4-chlorobenzaldehyde

Downstream raw materials:

methyl 2-(4-chlorophenyl)-2-(3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)acetate