(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester
CAS No.:177944-08-0
Molecular Formula:C₂₄H₂₇NO₄Si
Molecular Weight:421.568
Hs Code.:

Synonyms:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

There total 8 articles about (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 443126-87-2
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

: 177944-08-0
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In pyridine;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 89-51-0
Homophthalic acid

: 177944-08-0
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / LiAlH₄

2: 72 percent / LiCl, collidine / dimethylformamide

3: 82 percent / t-BuOK / diethyl ether / 0 °C

4: 96 percent / NaI / acetone

5: 1.) BuLi / 1.) HMPA

6: 100 percent / 1.) 0.5N HCl, 2.) LiOH

7: 73 percent / Na₂CO₃ / H₂O

8: 82 percent / EDC / pyridine

With 2,3,5-trimethyl-pyridine; hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; lithium chloride; In pyridine; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 6346-00-5
2-(2-hydroxyethyl)benzyl alcohol

: 177944-08-0
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / LiCl, collidine / dimethylformamide

2: 82 percent / t-BuOK / diethyl ether / 0 °C

3: 96 percent / NaI / acetone

4: 1.) BuLi / 1.) HMPA

5: 100 percent / 1.) 0.5N HCl, 2.) LiOH

6: 73 percent / Na₂CO₃ / H₂O

7: 82 percent / EDC / pyridine

With 2,3,5-trimethyl-pyridine; hydrogenchloride; lithium hydroxide; n-butyllithium; potassium tert-butylate; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; lithium chloride; In pyridine; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0960-894X(96)00149-7