(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

Base Information

Chemical Name:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid
CAS No.:443126-87-2
Molecular Formula:C₁₉H₁₅NO₄
Molecular Weight:321.332
Hs Code.:

Synonyms:(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

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Technology Process of (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

There total 7 articles about (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 22509-74-6
N-ethoxycarbonylphthalimide

: 178035-46-6
(S)-2-Amino-3-(2-vinyl-phenyl)-propionic acid

: 443126-87-2
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

Guidance literature:: With sodium carbonate; In water;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 89-51-0
Homophthalic acid

: 443126-87-2
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / LiAlH₄

2: 72 percent / LiCl, collidine / dimethylformamide

3: 82 percent / t-BuOK / diethyl ether / 0 °C

4: 96 percent / NaI / acetone

5: 1.) BuLi / 1.) HMPA

6: 100 percent / 1.) 0.5N HCl, 2.) LiOH

7: 73 percent / Na₂CO₃ / H₂O

With 2,3,5-trimethyl-pyridine; hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; sodium carbonate; sodium iodide; lithium chloride; In diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 6346-00-5
2-(2-hydroxyethyl)benzyl alcohol

: 443126-87-2
(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(2-vinyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / LiCl, collidine / dimethylformamide

2: 82 percent / t-BuOK / diethyl ether / 0 °C

3: 96 percent / NaI / acetone

4: 1.) BuLi / 1.) HMPA

5: 100 percent / 1.) 0.5N HCl, 2.) LiOH

6: 73 percent / Na₂CO₃ / H₂O

With 2,3,5-trimethyl-pyridine; hydrogenchloride; lithium hydroxide; n-butyllithium; potassium tert-butylate; sodium carbonate; sodium iodide; lithium chloride; In diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0960-894X(96)00149-7