(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester
CAS No.:443126-89-4
Molecular Formula:C₃₃H₄₆N₂O₆Si
Molecular Weight:594.824
Hs Code.:

(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

There total 9 articles about (S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6346-00-5
2-(2-hydroxyethyl)benzyl alcohol

: 443126-89-4
(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / LiCl, collidine / dimethylformamide

2: 82 percent / t-BuOK / diethyl ether / 0 °C

3: 96 percent / NaI / acetone

4: 1.) BuLi / 1.) HMPA

5: 100 percent / 1.) 0.5N HCl, 2.) LiOH

6: 73 percent / Na₂CO₃ / H₂O

7: 82 percent / EDC / pyridine

8: 85 percent / 1.) O₃, 2.) DMS

9: NaBH₃CN

With 2,3,5-trimethyl-pyridine; hydrogenchloride; lithium hydroxide; n-butyllithium; 2,3-dimercapto-succinic acid; potassium tert-butylate; sodium cyanoborohydride; sodium carbonate; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; lithium chloride; In pyridine; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 22570-84-9
2-chloromethylstyrene

: 443126-89-4
(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / NaI / acetone

2: 1.) BuLi / 1.) HMPA

3: 100 percent / 1.) 0.5N HCl, 2.) LiOH

4: 73 percent / Na₂CO₃ / H₂O

5: 82 percent / EDC / pyridine

6: 85 percent / 1.) O₃, 2.) DMS

7: NaBH₃CN

With hydrogenchloride; lithium hydroxide; n-butyllithium; 2,3-dimercapto-succinic acid; sodium cyanoborohydride; sodium carbonate; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; In pyridine; water; acetone;
DOI:10.1016/0960-894X(96)00149-7

Reference yield:

: 149296-21-9
1-Chloromethyl-2-(2-mesyloxyethyl)benzene

: 443126-89-4
(S)-2-{2-[(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-benzylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / t-BuOK / diethyl ether / 0 °C

2: 96 percent / NaI / acetone

3: 1.) BuLi / 1.) HMPA

4: 100 percent / 1.) 0.5N HCl, 2.) LiOH

5: 73 percent / Na₂CO₃ / H₂O

6: 82 percent / EDC / pyridine

7: 85 percent / 1.) O₃, 2.) DMS

8: NaBH₃CN

With hydrogenchloride; lithium hydroxide; n-butyllithium; 2,3-dimercapto-succinic acid; potassium tert-butylate; sodium cyanoborohydride; sodium carbonate; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; In pyridine; diethyl ether; water; acetone;
DOI:10.1016/0960-894X(96)00149-7