4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride

Base Information

• Chemical Name: 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride
• CAS No.: 1465783-89-4
• Molecular Formula: C₃₂H₃₈N₄O₄S*ClH
• Molecular Weight: 629.106

Synonyms:4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride

Chemical Property of 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride

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Technology Process of 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride

There total 6 articles about 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrotosylate (1465783-87-2) → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrochloride (1465783-89-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1002/jlcr.3107

Reference yield:

benzyl (S)-[4-methylpiperazin-1-carbonyl]amino-3-[14C6]phenyl[14C3]propionate (1465783-84-9) → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrochloride (1465783-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Pd/C (30%); hydrogen / ethanol / 16 h / 760.05 Torr

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere

2.2: 2 h / -30 - -15 °C / Inert atmosphere

2.3: 16 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; Pd/C (30%); hydrogen; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3107

Reference yield:

C(14)C9H9NO3 → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrochloride (1465783-89-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 72 h / 0 - 20 °C / Inert atmosphere

2.1: pyridine / toluene; dichloromethane / -40 °C / Inert atmosphere

3.1: tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

4.1: Pd/C (30%); hydrogen / ethanol / 16 h / 760.05 Torr

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere

5.2: 2 h / -30 - -15 °C / Inert atmosphere

5.3: 16 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / diethyl ether; dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; pyridine; hydrogenchloride; Pd/C (30%); hydrogen; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/jlcr.3107

upstream raw materials:

benzyl (S)-[4-methylpiperazin-1-carbonyl]amino-3-[14C₆]phenyl[14C₃]propionate

4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate

[14C(U)]-(L)-phenylalanine benzyl ester hydrochloride

benzyl (S)-2-isocyanato-3-[14C₆]phenyl[14C₃]propionate

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