octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

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Chemical Name:octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide
CAS No.:944457-65-2
Molecular Formula:C₃₈H₄₁N₅O₄
Molecular Weight:631.775
Hs Code.:

Synonyms:octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

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Chemical Property of octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

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Technology Process of octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

There total 5 articles about octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 944457-72-1
[1-[4'-(7-benzyloxycarbamoyl-heptanoylamino)biphenyl-2-ylcarbamoyl]-2-(1H-indol-3-yl)ethyl]carbamic acid tert-butyl ester

: 944457-65-2
octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: [1-[4'-(7-benzyloxycarbamoyl-heptanoylamino)biphenyl-2-ylcarbamoyl]-2-(1H-indol-3-yl)ethyl]carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium hydrogencarbonate; In diethyl ether; dichloromethane; water;

Reference yield:

: 944457-70-9
[2-(1H-indol-3-yl)-1-(4'-nitro-biphenyl-2-ylcarbamoyl)ethyl]carbamic acid tert-butyl ester

: 944457-65-2
octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / H₂ / Pd(OH)2/C / methanol; CH₂Cl₂ / 4 h / 20 °C

2: 70 percent / DIPEA; PyBOP / dimethylformamide / 20 °C

3: TFA / CH₂Cl₂ / 2 h / 0 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070178x

Reference yield:

: 6272-52-2
2-(4-nitrophenyl)aniline

: 944457-65-2
octanedioic acid {2'-[2-amino-3-(1H-indol-3-yl)propionylamino]biphenyl-4-yl}amide benzyloxyamide

Guidance literature:: Multi-step reaction with 4 steps

1: 58.2 percent / pyridine; POCl₃ / 1 h / -15 °C

2: 83 percent / H₂ / Pd(OH)2/C / methanol; CH₂Cl₂ / 4 h / 20 °C

3: 70 percent / DIPEA; PyBOP / dimethylformamide / 20 °C

4: TFA / CH₂Cl₂ / 2 h / 0 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm070178x