4'-Nitro-[1,1'-biphenyl]-2-amine

Base Information

• Chemical Name: 4'-Nitro-[1,1'-biphenyl]-2-amine
• CAS No.: 6272-52-2
• Molecular Formula: C12H10 N2 O2
• Molecular Weight: 214.224
• Hs Code.: 2921499090
• European Community (EC) Number: 228-462-0
• NSC Number: 30863
• UNII: A6SQ344JTL
• DSSTox Substance ID: DTXSID30211804
• Nikkaji Number: J81.173D
• Wikidata: Q83086786
• ChEMBL ID: CHEMBL352290
• Mol file: 6272-52-2.mol

Synonyms:6272-52-2;4'-Nitro-biphenyl-2-ylamine;4'-Nitro-[1,1'-biphenyl]-2-amine;2-(4-nitrophenyl)aniline;2-Amino-4'-nitrobiphenyl;4'-Nitro-2-biphenylamine;2-BIPHENYLAMINE, 4'-NITRO-;EINECS 228-462-0;NSC 30863;BRN 2806990;[1,1'-Biphenyl]-2-amine, 4'-nitro-;MLS002639355;4'-nitro[1,1'-biphenyl]-2-amine;NSC-30863;4'-Nitro-(1,1'-biphenyl)-2-amine;4-12-00-03236 (Beilstein Handbook Reference);(1,1'-Biphenyl)-2-amine, 4'-nitro-;NSC30863;4-nitrophenyl benzenamine;4'-Nitro-2-aminobiphenyl;4-Nitrobiphenyl-2-ylamine;A6SQ344JTL;CHEMBL352290;SCHEMBL3010864;DTXSID30211804;4'-NITROBIPHENYL-2-AMINE;HMS3091E13;[2-(4-nitrophenyl)-phenyl]-amine;AMY23533;MFCD01740422;AKOS024260529;AB09889;LS-44150;SMR001548800;CS-0341627;FT-0654064;A833953

Chemical Property of 4'-Nitro-[1,1'-biphenyl]-2-amine

Chemical Property:

• Boiling Point: 385.6oC at 760 mmHg
• Flash Point: 187oC
• PSA: 71.84000
• Density: 1.268g/cm3
• LogP: 3.94840
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 214.074227566
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

97% ^*data from raw suppliers

4''-Nitro-biphenyl-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)[N+](=O)[O-])N

Technology Process of 4'-Nitro-[1,1'-biphenyl]-2-amine

There total 18 articles about 4'-Nitro-[1,1'-biphenyl]-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-iodophenylamine (615-43-0) + 4-nitrophenylboronic acid (24067-17-2) → 2-(4-nitrophenyl)aniline (6272-52-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; In tetrahydrofuran; for 12h; Reflux;

DOI:10.1021/jm3003679

Reference yield: 70.0%

2-phenylaniline (90-41-5) → 2-(4-nitrophenyl)aniline (6272-52-2)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃;

DOI:10.1039/c39930001713

Reference yield:

sulfuric acid (7664-93-9) + 2-phenylaniline (90-41-5) → 2-(4-nitrophenyl)aniline (6272-52-2) + 4,4'-dinitro-2-biphenylamine (51787-75-8)

Guidance literature:

DOI:10.1039/jr9490000703

upstream raw materials:

2,4'-dinitrobiphenyl

2-acetamino-4'-nitro-1,1'-biphenyl

ethyl nitrate

2-phenylaniline

Downstream raw materials:

4,4'-dinitro-2-biphenylamine

nicotinic acid-(4'-nitro-biphenyl-2-ylamide)

N-(4'-nitro-biphenyl-2-yl)-benzamide

3-nitro-6-phenylphenanthridine