Technology Process of 5'-benzoyl-2'-deoxy-2'-iodo-3'-O-mesyl-2',3'-secothymidine
There total 5 articles about 5'-benzoyl-2'-deoxy-2'-iodo-3'-O-mesyl-2',3'-secothymidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 89 percent / DBU / CH2Cl2 / 2 h / Ambient temperature
2: 55 percent / hydroiodic acid / dimethylformamide / 16 h / Ambient temperature
With
hydrogen iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85449-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: copper(II) sulfate; sulfuric acid / 24 h / 15 °C / Large scale
2: pyridine / 5 h / 15 °C / Large scale
3: water; trifluoroacetic acid / 10 h / 15 °C / Large scale
4: sodium periodate / ethanol; water / 2 h / 15 °C / Darkness
5: water; sodium tetrahydroborate; ethanol / 1 h / 0 - 15 °C
6: triethylamine / dichloromethane / 4 h / 0 °C
7: hydrogen iodide / N,N-dimethyl-formamide / 0.5 h / 15 °C
With
pyridine; sodium tetrahydroborate; sodium periodate; ethanol; sulfuric acid; water; hydrogen iodide; copper(II) sulfate; triethylamine; trifluoroacetic acid;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
