3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Base Information

Chemical Name:3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine
CAS No.:130515-61-6
Molecular Formula:C₁₇H₁₉N₅O₅
Molecular Weight:373.368
Hs Code.:

Synonyms:3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Suppliers and Price of 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

There total 7 articles about 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 130515-58-1
5'-O-benzoyl-2'-deoxy-3'-O-mesyl-2',3'-secothymidine

: 130515-61-6
3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;
DOI:10.1016/S0040-4020(01)85449-1

Reference yield:

: 130515-51-4
1-[1-(1-benzoyloxymethyl-2-hydroxyethoxy)-2-hydroxyethyl]thymine

: 130515-61-6
3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / 2 h / 0 °C

2: 89 percent / DBU / CH₂Cl₂ / 2 h / Ambient temperature

3: 55 percent / hydroiodic acid / dimethylformamide / 16 h / Ambient temperature

4: 90 percent / sodium acetate trihydrate, H₂ / Pd/C / dioxane

5: 72 percent / lithium azide / dimethylformamide / 2 h / 100 °C

With pyridine; lithium azide; hydrogen iodide; hydrogen; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85449-1

Reference yield:

: 130515-49-0
5'-O-benzoylribothymidine dialdehyde

: 130515-61-6
3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / sodium borohydride / ethanol; H₂O

2: 82 percent / pyridine / 2 h / 0 °C

3: 89 percent / DBU / CH₂Cl₂ / 2 h / Ambient temperature

4: 55 percent / hydroiodic acid / dimethylformamide / 16 h / Ambient temperature

5: 90 percent / sodium acetate trihydrate, H₂ / Pd/C / dioxane

6: 72 percent / lithium azide / dimethylformamide / 2 h / 100 °C

With pyridine; sodium tetrahydroborate; lithium azide; hydrogen iodide; hydrogen; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85449-1