Technology Process of 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine
There total 7 articles about 3'-Azido-5'-O-benzoyl-2',3'-dideoxy-2',3'-secothymidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / pyridine / 2 h / 0 °C
2: 89 percent / DBU / CH2Cl2 / 2 h / Ambient temperature
3: 55 percent / hydroiodic acid / dimethylformamide / 16 h / Ambient temperature
4: 90 percent / sodium acetate trihydrate, H2 / Pd/C / dioxane
5: 72 percent / lithium azide / dimethylformamide / 2 h / 100 °C
With
pyridine; lithium azide; hydrogen iodide; hydrogen; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85449-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / sodium borohydride / ethanol; H2O
2: 82 percent / pyridine / 2 h / 0 °C
3: 89 percent / DBU / CH2Cl2 / 2 h / Ambient temperature
4: 55 percent / hydroiodic acid / dimethylformamide / 16 h / Ambient temperature
5: 90 percent / sodium acetate trihydrate, H2 / Pd/C / dioxane
6: 72 percent / lithium azide / dimethylformamide / 2 h / 100 °C
With
pyridine; sodium tetrahydroborate; lithium azide; hydrogen iodide; hydrogen; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85449-1
