(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

Base Information

Chemical Name:(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid
CAS No.:1301701-45-0
Molecular Formula:C₁₄H₁₄F₃NO₃
Molecular Weight:301.265
Hs Code.:

Synonyms:(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

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Technology Process of (2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

There total 1 articles about (2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1301701-44-9
(E)-2-phenylbut-2-enyl 2-(2,2,2-trifluoroacetamido)acetate

: 1301701-45-0
(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

Guidance literature:: With n-butyllithium; quinindine; aluminum isopropoxide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/np100877h

Reference yield: 81.0%

: 1301701-45-0
(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 1301701-46-1
(2S,3R)-methyl 3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoate

Guidance literature:: In methanol; hexane; toluene; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/np100877h

Reference yield: 58.0%

: 1694-31-1
tert-butyl acetoacetate

: 1301701-45-0
(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

: 1301701-47-2
(2S,3R)-tert-butyl 3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoate

Guidance literature:: tert-butyl acetoacetate; (2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid; With sulfuric acid; at 20 ℃; for 20h; Inert atmosphere;

With sodium hydrogencarbonate; sodium chloride; In ethyl acetate;
DOI:10.1021/np100877h