(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

Base Information

Chemical Name:(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate
CAS No.:1301701-49-4
Molecular Formula:C₁₇H₂₀F₃NO₄
Molecular Weight:359.345
Hs Code.:

Synonyms:(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

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Chemical Property of (2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

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Technology Process of (2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

There total 2 articles about (2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1301701-47-2
(2S,3R)-tert-butyl 3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoate

: 1301701-49-4
(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

Guidance literature:: (2S,3R)-tert-butyl 3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoate; With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

With sodium periodate; In tetrahydrofuran; water; for 4h;
DOI:10.1021/np100877h

Reference yield:

: 1301701-45-0
(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

: 1301701-49-4
(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 20 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.2: 4 h

With osmium(VIII) oxide; sulfuric acid; water; 4-methylmorpholine N-oxide; In tetrahydrofuran;
DOI:10.1021/np100877h

Reference yield: 47.0%

: 1301701-49-4
(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

: 1301701-50-7
(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Guidance literature:: With sodium cyanoborohydride; zinc(II) iodide; In 1,2-dichloro-ethane; at 75 ℃; for 10h; Inert atmosphere;
DOI:10.1021/np100877h