(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Base Information

Chemical Name:(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran
CAS No.:1301701-50-7
Molecular Formula:C₁₃H₁₂F₃NO₃
Molecular Weight:287.238
Hs Code.:

Synonyms:(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Suppliers and Price of (3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

There total 3 articles about (3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1301701-49-4
(2S,3S)-tert-butyl 3-methyl-4-oxo-4-phenyl-2-(2,2,2-trifluoroacetamido)-butanoate

: 1301701-50-7
(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Guidance literature:: With sodium cyanoborohydride; zinc(II) iodide; In 1,2-dichloro-ethane; at 75 ℃; for 10h; Inert atmosphere;
DOI:10.1021/np100877h

Reference yield:

: 1301701-45-0
(2S,3R)-3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoic acid

: 1301701-50-7
(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 20 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.2: 4 h

3.1: sodium cyanoborohydride; zinc(II) iodide / 1,2-dichloro-ethane / 10 h / 75 °C / Inert atmosphere

With osmium(VIII) oxide; sulfuric acid; water; sodium cyanoborohydride; 4-methylmorpholine N-oxide; zinc(II) iodide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/np100877h

Reference yield:

: 1301701-47-2
(2S,3R)-tert-butyl 3-methyl-4-phenyl-2-(2,2,2-trifluoroacetamido)-pent-4-enoate

: 1301701-50-7
(3S,4S)-3-(2',2',2'-trifluoroacetamido)-4-methyl-2-oxo-5-phenyl-tetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

1.2: 4 h

2.1: sodium cyanoborohydride; zinc(II) iodide / 1,2-dichloro-ethane / 10 h / 75 °C / Inert atmosphere

With osmium(VIII) oxide; water; sodium cyanoborohydride; 4-methylmorpholine N-oxide; zinc(II) iodide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/np100877h