2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Base Information

Chemical Name:2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid
CAS No.:1477524-01-8
Molecular Formula:C₂₆H₂₈N₄O₄
Molecular Weight:460.533
Hs Code.:

Synonyms:2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

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Chemical Property of 2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

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Technology Process of 2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

There total 14 articles about 2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetaldehyde

: 1477524-01-8
2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: With sodium chlorite; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 1477524-68-7
1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

: 1477524-01-8
2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.5 h / -78 - 0 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

3.1: 2-methyl-but-2-ene; sodium chlorite / water; tetrahydrofuran; tert-butyl alcohol / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium chlorite; 2-methyl-but-2-ene; lithium hexamethyldisilazane; In tetrahydrofuran; water; tert-butyl alcohol;

Reference yield:

: 1449661-70-4
4-trifluoromethanesulfonyloxycyclohex-3-ene-1,1-dicarboxylic acid diethyl ester

: 1477524-01-8
2-(1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

1.2: 1 h / 100 °C / Inert atmosphere; Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: N-Bromosuccinimide / dichloromethane; tetrahydrofuran / -78 - 20 °C

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene; tetrahydrofuran / 3 h / 40 - 100 °C / Inert atmosphere

5.1: dichloromethane; tetrahydrofuran / 1 h / 20 °C

5.2: 1 h / 20 °C

5.3: 16 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

7.2: 0.5 h / -78 - 0 °C

8.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

9.1: 2-methyl-but-2-ene; sodium chlorite / water; tetrahydrofuran; tert-butyl alcohol / 1 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium chlorite; N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-methyl-but-2-ene; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene; tert-butyl alcohol; 1.1: |Suzuki Coupling;