1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

Base Information

Chemical Name:1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde
CAS No.:1477524-68-7
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

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Chemical Property of 1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

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Technology Process of 1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

There total 11 articles about 1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: (1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octan-4-yl)methanol

: 1477524-68-7
1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1449661-70-4
4-trifluoromethanesulfonyloxycyclohex-3-ene-1,1-dicarboxylic acid diethyl ester

: 1477524-68-7
1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

1.2: 1 h / 100 °C / Inert atmosphere; Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: N-Bromosuccinimide / dichloromethane; tetrahydrofuran / -78 - 20 °C

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene; tetrahydrofuran / 3 h / 40 - 100 °C / Inert atmosphere

5.1: dichloromethane; tetrahydrofuran / 1 h / 20 °C

5.2: 1 h / 20 °C

5.3: 16 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene; 1.1: |Suzuki Coupling;

Reference yield:

: 55704-60-4
4-oxo-cyclohexane-1,1-dicarboxylic acid diethyl ester

: 1477524-68-7
1-(4-(5-((5-cyclobutyl-1,3,4-oxadiazol-2-yl)amino)pyridin-2-yl)phenyl)-2-oxabicyclo[2.2.2]octane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.53 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

2.2: 1 h / 100 °C / Inert atmosphere; Sealed tube

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: N-Bromosuccinimide / dichloromethane; tetrahydrofuran / -78 - 20 °C

5.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene; tetrahydrofuran / 3 h / 40 - 100 °C / Inert atmosphere

6.1: dichloromethane; tetrahydrofuran / 1 h / 20 °C

6.2: 1 h / 20 °C

6.3: 16 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; 2.1: |Suzuki Coupling;