N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

Base Information

Chemical Name:N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine
CAS No.:1229246-36-9
Molecular Formula:C₁₄H₁₇Cl₂NO
Molecular Weight:286.201
Hs Code.:

Synonyms:N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

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Chemical Property of N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

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Technology Process of N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

There total 5 articles about N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194490-06-6
N-[(5-bromo-2,3-dichlorophenyl)methyl]cyclopropanamine

: 165059-42-7,934342-48-0
(E)-3-methoxy-1-propenylboronic acid pinacol ester

: 1229246-36-9
N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

Guidance literature:: With sodium carbonate; trans-dichlorobis(triphenylphosphine)palladium(II); In propan-1-ol; water; N,N-dimethyl-formamide; at 90 ℃; for 8h; Inert atmosphere of nitrogen;

Reference yield:

: 1229246-37-0
5-bromo-2,3-dichlorobenzaldehyde

: 1229246-36-9
N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium sulfate / dichloromethane / 20 °C

2: magnesium sulfate / dichloromethane / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C

4: sodium carbonate / trans-dichlorobis(triphenylphosphine)palladium(II) / propan-1-ol; water; N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere of nitrogen

With sodium tetrahydroborate; sodium carbonate; magnesium sulfate; trans-dichlorobis(triphenylphosphine)palladium(II); In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

: C₁₀H₈BrCl₂N

: 1229246-36-9
N-({2,3-dichloro-5-[(1E)-3-(methyloxy)-1-propen-1-yl]phenyl}methyl)cyclopropanamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C

2: sodium carbonate / trans-dichlorobis(triphenylphosphine)palladium(II) / propan-1-ol; water; N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere of nitrogen

With sodium tetrahydroborate; sodium carbonate; trans-dichlorobis(triphenylphosphine)palladium(II); In tetrahydrofuran; methanol; propan-1-ol; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;