methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

Base Information

Chemical Name:methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate
CAS No.:165537-95-1
Molecular Formula:C₂₁H₂₄ClNO₄S
Molecular Weight:421.945
Hs Code.:

Synonyms:methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

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Chemical Property of methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

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Technology Process of methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

There total 6 articles about methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165537-94-0
(E)-3-[6-(4-Chloro-benzenesulfonylamino)-2-methyl-5,6,7,8-tetrahydro-naphthalen-1-yl]-acrylic acid methyl ester

: 165537-95-1
methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1016/S0960-894X(98)00220-0

Reference yield:

: C₁₅H₂₁NO₂

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 165537-95-1
methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

Guidance literature:: With hydrogen; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1039/c4ob02302a

Reference yield:

: methyl 3-(6-hydroxy-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

: 165537-95-1
methyl 3-(6-(4-chlorophenylsulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -15 °C / Inert atmosphere

1.2: 12.5 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon / ethyl acetate

3.1: hydrogen / ethyl acetate / 12 h / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 1.1: |Mitsunobu Displacement;
DOI:10.1039/c4ob02302a