8-D-tryptophan-somatostatin

Base Information

Chemical Name:8-D-tryptophan-somatostatin
CAS No.:58976-46-8
Molecular Formula:C₇₆H₁₀₄N₁₈O₁₉S₂
Molecular Weight:1637.9
Hs Code.:
UNII:O1208M5SQ8
ChEMBL ID:CHEMBL1823873
Wikidata:Q27285185
Mol file:58976-46-8.mol

Synonyms:(D-Tryp(8))SRIF-14;8-Trp-somatostatin;8-Trp-SRIF-14;8-Trp-SRIH;8-tryptophan-somatostatin;somatostatin, Trp(8)-;somatostatin, tryptophan(8)-;SRIF-14, Trp(8)-;SRIF-14, tryptophyl(8)-

Suppliers and Price of 8-D-tryptophan-somatostatin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
[D-TRP8 ]-SOMATOSTATIN 95.00%
5MG
$ 876.65

American Custom Chemicals Corporation
[D-TRP8 ]-SOMATOSTATIN 95.00%
1MG
$ 618.50

American Custom Chemicals Corporation
[D-TRP8 ]-SOMATOSTATIN 95.00%
0.5MG
$ 559.02

Total 17 raw suppliers

Chemical Property of 8-D-tryptophan-somatostatin

Chemical Property:

Appearance/Colour:White powder
PSA：663.83000
LogP:2.28620
Storage Temp.:−20°C
XLogP3:-3.1
Hydrogen Bond Donor Count:22
Hydrogen Bond Acceptor Count:24
Rotatable Bond Count:26
Exact Mass:1636.71665551
Heavy Atom Count:115
Complexity:3240

Purity/Quality:

99%, ^*data from raw suppliers

[D-TRP8 ]-SOMATOSTATIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)CNC(=O)C(C)N)C(=O)O)CO)C(C)O)CC6=CC=CC=C6)O
Isomeric SMILES:C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)CNC(=O)[C@H](C)N)C(=O)O)CO)[C@@H](C)O)CC6=CC=CC=C6)O

Technology Process of 8-D-tryptophan-somatostatin

There total 2 articles about 8-D-tryptophan-somatostatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄₅H₁₈₉N₁₈O₂₈PolS₂

: 58976-46-8,66610-27-3,61950-59-2
[D-Trp₈]-SRIF

Guidance literature:: C₁₄₅H₁₈₉N₁₈O₂₈PolS₂; With 2,2,2-trifluoroethanol; acetic acid; In dichloromethane; for 2h;

With iodine; at 25 ℃; for 0.25h;

With water; methoxybenzene; trifluoroacetic acid; In dichloromethane; for 4h;
DOI:10.1002/anie.201106406

Reference yield:

: 4530-20-5
BOC-glycine

: 15761-38-3
L-N-Boc-Ala

: C₁₆H₂₂NO₄PolS

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 23680-31-1
BOC-O-benzyl-L-serine

: 18942-46-6,58290-35-0
N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteine

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 5241-64-5
Boc-D-Trp-OH

: 65420-40-8
(S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid

: 58976-46-8,66610-27-3,61950-59-2
[D-Trp₈]-SRIF

Guidance literature:: C₁₆H₂₂NO₄PolS; With 3-methyl-phenol; trifluoroacetic acid; for 0.25h; Automated synthesizer; solid phase reaction;

BOC-O-benzyl-L-serine; With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide; for 1h; Automated synthesizer; solid phase reaction;

BOC-glycine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-O-benzyl-L-threonine; N-(tert-butyloxycarbonyl)-S-(4-methoxybenzyl)cysteine; Boc-(S)-Lys(2-Cl-Z)-OH; Boc-D-Trp-OH; (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid; Further stages;
DOI:10.1021/jm200307v