Tetradecanamide, N-[3-(dimethylamino)propyl]-

Base Information

• Chemical Name: Tetradecanamide, N-[3-(dimethylamino)propyl]-
• CAS No.: 45267-19-4
• Molecular Formula: C19H40 N2 O
• Molecular Weight: 312.539
• Hs Code.: 2924199090
• European Community (EC) Number: 256-214-1
• UNII: YXS2X34V8W
• DSSTox Substance ID: DTXSID2068470
• Nikkaji Number: J319.960F
• Wikidata: Q27294767
• Mol file: 45267-19-4.mol

Synonyms:Aldox;M-dimethylamine;MADP solution;myristamidopropyl dimethylamine

Chemical Property of Tetradecanamide, N-[3-(dimethylamino)propyl]-

Chemical Property:

• Vapor Pressure: 3.84E-08mmHg at 25°C
• Melting Point: 49-51°C
• Boiling Point: 445.8°Cat760mmHg
• PKA: 16.29±0.46(Predicted)
• Flash Point: 223.4°C
• PSA: 32.34000
• Density: 0.879g/cm³
• LogP: 5.14630
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 6.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 16
• Exact Mass: 312.314063904
• Heavy Atom Count: 22
• Complexity: 242

Purity/Quality:

98%,99%, ^*data from raw suppliers

Aldox ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCC(=O)NCCCN(C)C
• Uses: Myristamidopropyl dimethylamine (MAPD), present as Aldox in Opti-Free Express Disinfecting Solution for contact lens care, was tested for its potential as a drug in treatment of Acanthamoeba keratitis. MAPD is an amidoamine compound that shows activity against Acanthamoeba as well as a variety of other causal agents of microbial keratitis.

Technology Process of Tetradecanamide, N-[3-(dimethylamino)propyl]-

There total 9 articles about Tetradecanamide, N-[3-(dimethylamino)propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

n-tetradecanoic acid (544-63-8) + 1-amino-3-(dimethylamino)propane (109-55-7) → myristamidopropyl dimethylamine (45267-19-4)

Guidance literature:

at 120 - 130 ℃;

DOI:10.1007/BF01149148

Reference yield: 82.0%

1,1-dimethylamino-3-aminopropane + n-tetradecanoic acid (544-63-8) → myristamidopropyl dimethylamine (45267-19-4)

Guidance literature:

In sodium hydroxide;

Reference yield: 65.0%

lauric acid (143-07-7) + 1-amino-3-(dimethylamino)propane (109-55-7) → myristamidopropyl dimethylamine (45267-19-4)

Guidance literature:

In toluene; for 48h; Reflux; Dean-Stark;

DOI:10.1016/j.ejmech.2020.113100

upstream raw materials:

myristonitrile

1-amino-3-(dimethylamino)propane

tetradecanoyl chloride

n-tetradecanoic acid

Downstream raw materials:

benzyl(dimethyl)[3-(tetradecanoylamino)propyl]ammonium chloride

N-(3-(dimethyl(4-methylbenzyl)ammonio)propyl)myristamide chloride

ES₀₀₁₄₂₇

ASB 14

Refernces

• 1、 Agafonova, Mariya N.,Chirkova, Milana N.,Druk, Anastasia Y.,Grishaev, Denis Y.,Kayumov, Airat R.,Kazakova, Renata R.,Krylova, Elena S.,Nikishova, Tatyana V.,Nikitina, Elena V.,Sabirova, Alina E.,Sapozhnikov, Sergey V.,Shtyrlin, Nikita V.,Shtyrlin, Yurii G.. "Design, synthesis, antibacterial activity and toxicity of novel quaternary ammonium compounds based on pyridoxine and fatty acids". . . Retrieved 2021/01/06.
• 2、 -. "A method for reducing betaine free acid in the process method of the (by machine translation)". Paragraph 0029; 0030; 0031. . Retrieved 2017/11/08.