3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on

Base Information

• Chemical Name: 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on
• CAS No.: 84102-03-4
• Molecular Formula: C₂₂H₂₂N₂O₂
• Molecular Weight: 346.429
• Mol file: 84102-03-4.mol

Synonyms:3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on

Chemical Property of 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on

There total 4 articles about 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Benzyloxyacetyl-5-methyl-1,3-cyclohexandion (84102-01-2) + phenylhydrazine (100-63-0) → 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on (84102-03-4)

Guidance literature:

In methanol; at 60 ℃; for 3h;

DOI:10.1002/jlac.198219821010

Reference yield:

Benzyloxyacetyl chloride (19810-31-2) → 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on (84102-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / tetrahydrofuran / 0.5 h / Ambient temperature

2: NaOC₂H₅ / CHCl₃ / 4 h / Heating

3: 88 percent / methanol / 3 h / 60 °C

With sodium ethanolate; In tetrahydrofuran; methanol; chloroform;

DOI:10.1002/jlac.198219821010

Reference yield:

benzyloxyacetic acid (30379-55-6) → 3-Benzyloxymethyl-1,5,6,7-tetrahydro-6-methyl-1-phenyl-4H-indazol-4-on (84102-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CHCl₃ / 40 °C

2: NaOC₂H₅ / CHCl₃ / 4 h / Heating

3: 88 percent / methanol / 3 h / 60 °C

With sodium ethanolate; In methanol; chloroform;

DOI:10.1002/jlac.198219821010

upstream raw materials:

2-Benzyloxyacetyl-5-methyl-1,3-cyclohexandion

phenylhydrazine

benzyloxyacetic acid

Benzyloxyacetyl chloride

Downstream raw materials:

1,5,6,7-Tetrahydro-3-hydroxymethyl-6-methyl-1-phenyl-4H-indazol-4-on