Technology Process of (2S,3R)-2-(benzyloxy)-3-(6-chloropurin-9-yl)nonane-8,9-diol
There total 9 articles about (2S,3R)-2-(benzyloxy)-3-(6-chloropurin-9-yl)nonane-8,9-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
perchloric acid;
In
acetonitrile;
for 2h;
Ambient temperature;
DOI:10.1021/jm00048a020
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / Li2CuCl4 / diethyl ether / 1 h / -78 °C
2: 97 percent / pyridine / 12 h / Ambient temperature
3: 96 percent / NaN3 / dimethylformamide / 0.75 h / Heating
4: 96 percent / LAH / diethyl ether / 2 h / Heating
5: 74 percent / n-Bu3N / pentan-1-ol / 48 h / Heating
6: 85 percent / conc. HCl / 24 h / Ambient temperature
7: 90 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature
8: 95 percent / 5percent HClO4 / acetonitrile / 2 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; perchloric acid; dilithium tetrachlorocuprate; tributyl-amine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; pentan-1-ol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00048a020
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 96 percent / Li2CuCl4 / diethyl ether / 1 h / -78 °C
2: 97 percent / pyridine / 12 h / Ambient temperature
3: 96 percent / NaN3 / dimethylformamide / 0.75 h / Heating
4: 96 percent / LAH / diethyl ether / 2 h / Heating
5: 74 percent / n-Bu3N / pentan-1-ol / 48 h / Heating
6: 85 percent / conc. HCl / 24 h / Ambient temperature
7: 90 percent / 85percent m-chloroperbenzoic acid / CH2Cl2 / Ambient temperature
8: 95 percent / 5percent HClO4 / acetonitrile / 2 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; perchloric acid; dilithium tetrachlorocuprate; tributyl-amine; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; pentan-1-ol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00048a020
