(1-Boc-piperidin-4-yl)acetonitrile

Base Information

• Chemical Name: (1-Boc-piperidin-4-yl)acetonitrile
• CAS No.: 256411-39-9
• Molecular Formula: C12H20N2O2
• Molecular Weight: 224.30
• Hs Code.: 2916399090
• Mol file: 256411-39-9.mol

Synonyms:4-(Cyanomethyl)piperidine-1-carboxylicacid tert-butyl ester;N-Boc-piperidine-4-acetonitrile;

Chemical Property of (1-Boc-piperidin-4-yl)acetonitrile

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 344.274 °C at 760 mmHg
• PKA: -1.91±0.40(Predicted)
• Flash Point: 162.011 °C
• PSA: 53.33000
• Density: 1.04 g/cm³
• LogP: 2.48508
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(Cyanomethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-Boc-piperidin-4-yl)acetonitrile

There total 19 articles about (1-Boc-piperidin-4-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester (197569-11-2) → tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (256411-39-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 3.5h;

Reference yield: 92.0%

tert-butyl 4-(formylmethyl)piperidine-1-carboxylate (142374-19-4) → tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (256411-39-9)

Guidance literature:

With O-(diphenylphosphinyl)hydroxylamine; In toluene; at 20 - 85 ℃; chemoselective reaction;

DOI:10.1021/jo301133y DOI:10.1021/jo301133y

Reference yield: 76.6%

sodium cyanide (773837-37-9) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6) → tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (256411-39-9)

Guidance literature:

In ethanol; water; at 20 - 80 ℃; for 24h;

DOI:10.1016/j.bmcl.2017.06.034

upstream raw materials:

4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

4-carbamoylmethyl-piperidine-1-carboxylic acid tert-butyl ester

potassium cyanide

Downstream raw materials:

2-(piperidin-4-yl)acetonitrile

tert-butyl 4-(7-(1-ethoxy-2-methyl-1-oxo-3-phenylpropan-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)piperidine-1-carboxylate

methyl 4-(7-(1-ethoxy-2-methyl-1-oxo-3-phenylpropan-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)piperidine-1-carboxylate

4-(N-hydroxycarbamimidoylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

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