(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

Base Information

Chemical Name:(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE
CAS No.:958329-43-6
Molecular Formula:C₂₁H₁₉ClF₃N₃O₃S
Molecular Weight:485.914
Hs Code.:

Synonyms:(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

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Chemical Property of (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

Chemical Property:

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Technology Process of (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

There total 4 articles about (R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 958332-58-6
N-{4-[(1R)-1-AMINOETHYL]-5-CHLORO-2-METHYLPHENYL}METHANESULFONAMIDE HYDROCHLORIDE

: 71082-51-4
7-trifluoromethyl-quinoline-3-carboxylic acid

: 958329-43-6
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 95-79-4
5-chloro-2-methyl-benzenamine

: 958329-43-6
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 20 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 24 h / 0 - 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

4.1: sodium tetrahydroborate / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere; Reflux

4.2: 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With pyridine; hydrogenchloride; aluminum (III) chloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 958332-57-5
N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-5-chloro-2-methyl-phenyl]methanesulfonamide

: 958329-43-6
(R)-N-(1-(2-CHLORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXAMIDE

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;