(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

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Chemical Name:(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate
CAS No.:1539320-73-4
Molecular Formula:C₂₉H₄₄N₄O₆
Molecular Weight:544.692
Hs Code.:

Synonyms:(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

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Chemical Property of (S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

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Technology Process of (S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

There total 8 articles about (S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1539320-68-7
C₂₄H₃₆N₄O₅

: 3282-30-2
pivaloyl chloride

: 1539320-73-4
(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c3ob42016g

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1539320-73-4
(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

6: trifluoroacetic acid / dichloromethane / 2 h

7: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3ob42016g

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 1539320-73-4
(S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h

2: trifluoroacetic acid / dichloromethane / 2 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 2 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h

6: trifluoroacetic acid / dichloromethane / 2 h

7: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3ob42016g