(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Base Information

Chemical Name:(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester
CAS No.:913730-58-2
Molecular Formula:C₃₁H₃₈Cl₂N₄O₆
Molecular Weight:633.572
Hs Code.:

Synonyms:(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Suppliers and Price of (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

There total 6 articles about (S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: cis-N-Boc-octahydroisoindole-1-carboxylic acid

: 4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

: 913730-58-2
(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

: C₃₁H₃₈Cl₂N₄O₆

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 13958-93-5
3,5-dichloropyridine-4-carboxylic acid

: 913730-58-2
(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

: C₃₁H₃₈Cl₂N₄O₆

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 5.75 h / Heating / reflux

2: 4-methyl-morpholine / dichloromethane / 1.08 h / 0 °C

3: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N,N-dimethyl-formamide; In dichloromethane; ethyl acetate;

Reference yield:

: 67630-00-6
N-(tert-butyloxycarbonyl)-4-nitro-L-phenylalanine ethyl ester

: 913730-58-2
(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

: C₃₁H₃₈Cl₂N₄O₆

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 - 2585.81 Torr

2: 4-methyl-morpholine / dichloromethane / 1.08 h / 0 °C

3: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate;