3,5-DICHLOROISONICOTINIC ACID

Base Information

• Chemical Name: 3,5-DICHLOROISONICOTINIC ACID
• CAS No.: 13958-93-5
• Molecular Formula: C6H3Cl2NO2
• Molecular Weight: 192.001
• Hs Code.: 2933399990
• Mol file: 13958-93-5.mol

Synonyms:Isonicotinicacid, 3,5-dichloro- (7CI,8CI);3,5-Dichloro-4-pyridinecarboxylic acid;

Chemical Property of 3,5-DICHLOROISONICOTINIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 230 °C (dec.)(lit.)
• Refractive Index: 1.606
• Boiling Point: 383.003 °C at 760 mmHg
• PKA: -1.16±0.25(Predicted)
• Flash Point: 185.434 °C
• PSA: 50.19000
• Density: 1.612 g/cm³
• LogP: 2.08660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichloroisonicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DICHLOROISONICOTINIC ACID

There total 7 articles about 3,5-DICHLOROISONICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

carbon dioxide (124-38-9,18923-20-1) + 3,5-dichloropyridine (2457-47-8) → 3,5-dichloropyridine-4-carboxylic acid (13958-93-5)

Guidance literature:

3,5-dichloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

carbon dioxide;

DOI:10.1016/S0960-894X(02)00918-6

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 3,5-dichloropyridine-4-carboxylic acid (13958-93-5) + 3-chloro-isonicotinic acid (88912-27-0)

Guidance literature:

With thionyl chloride; at 180 - 220 ℃; im Rohr und Zersetzen des Reaktionsprodukts mit Wasser;

Reference yield:

pyridine-4-carboxylic acid (55-22-1) + thionyl chloride (7719-09-7) → 3,5-dichloropyridine-4-carboxylic acid (13958-93-5) + 3-chloro-isonicotinic acid (88912-27-0)

Guidance literature:

at 180 - 220 ℃; im Rohr und nachfolgend Zersetzen mit Wasser;

upstream raw materials:

pyridine-4-carboxylic acid

tetrachloro-isonicotinoyl chloride

carbon dioxide

3,5-dichloropyridine

Downstream raw materials:

3,5-dichloro-4-(chloromethyl)pyridine

3,5-dichloro-N-((2-methyl-2-azabicyclo[2.2.2]octan-1-yl)(phenyl)methyl)isonicotinamide

Refernces

• 1、 Dai, Yujia,Hartandi, Kresna,Soni, Niru B.,Pease, Lori J.,Reuter, David R.,Olson, Amanda M.,Osterling, Donald J.,Doktor, Stella Z.,Albert, Daniel H.,Bouska, Jennifer J.,Glaser, Keith B.,Marcotte, Patrick A.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.. "Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors". . p. 386 - 390. Retrieved 2008/04/03.
• 2、 -. "PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES". Page 42. . Retrieved 2010/02/06.