(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

Base Information

Chemical Name:(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride
CAS No.:913730-59-3
Molecular Formula:C₂₆H₃₀Cl₂N₄O₄*ClH
Molecular Weight:569.916
Hs Code.:

Synonyms:(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

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Chemical Property of (S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

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Technology Process of (S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

There total 8 articles about (S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 913730-58-2
(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

: 913730-59-3
(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 67630-00-6
N-(tert-butyloxycarbonyl)-4-nitro-L-phenylalanine ethyl ester

: 913730-59-3
(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 2068.65 - 2585.81 Torr

2: 4-methyl-morpholine / dichloromethane / 1.08 h / 0 °C

3: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

5: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 13958-93-5
3,5-dichloropyridine-4-carboxylic acid

: 913730-59-3
(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 5.75 h / Heating / reflux

2: 4-methyl-morpholine / dichloromethane / 1.08 h / 0 °C

3: hydrogenchloride / ethyl acetate / 2 h / 20 °C

4: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0 - 20 °C

5: hydrogenchloride / 1,4-dioxane; dichloromethane; ethyl acetate

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; ethyl acetate;