3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

Base Information

Chemical Name:3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile
CAS No.:855302-03-3
Molecular Formula:C₁₈H₂₂N₂O₂
Molecular Weight:298.385
Hs Code.:

Synonyms:3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

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Chemical Property of 3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

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Technology Process of 3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

There total 3 articles about 3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855301-94-9
6-phenyl-2,3,5,6,9,10-hexahydro-1H-4-oxa-6a-azacyclopenta[d]naphthalen-3a-ylamine

: 855302-03-3
3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: citric acid / CH₂Cl₂ / 0.67 h

2: 3.01 g / NaNO₂; hydrochloric acid / tetrahydrofuran / 0.08 h / 20 °C

With hydrogenchloride; citric acid; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo050258d

Reference yield:

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 855302-03-3
3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropylamine; n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: lithium; naphthalene / tetrahydrofuran / 0.33 h / -78 °C

3.1: citric acid / CH₂Cl₂ / 0.67 h

4.1: 3.01 g / NaNO₂; hydrochloric acid / tetrahydrofuran / 0.08 h / 20 °C

With hydrogenchloride; n-butyllithium; naphthalene; lithium; diisopropylamine; citric acid; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo050258d

Reference yield:

: 855301-93-8
2H-Hexahydro-2-(3-chloropropyl)-2-cyano-6-phenyloxazolo<3,2-a>pyridne

: 855302-03-3
3a-hydroxy-6-phenyldecahydro-4-oxa-6a-azacyclopenta[d]naphthalene-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: lithium; naphthalene / tetrahydrofuran / 0.33 h / -78 °C

2: citric acid / CH₂Cl₂ / 0.67 h

3: 3.01 g / NaNO₂; hydrochloric acid / tetrahydrofuran / 0.08 h / 20 °C

With hydrogenchloride; naphthalene; lithium; citric acid; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo050258d