Technology Process of rac-tert-butyl 7,8-dihydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate
There total 7 articles about rac-tert-butyl 7,8-dihydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 2,3-diphenylpyrido[2,3-b]pyrazine-5(6H)-carboxylate;
With
potassium permanganate; methyl tributylammonium chloride;
In
dichloromethane;
at 0 - 5 ℃;
for 2h;
Inert atmosphere;
With
sodium hydrogensulfite;
In
dichloromethane; water;
at 0 - 5 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation
2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr
3.1: dmap / tetrahydrofuran / 125 h / 20 °C
4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C / Inert atmosphere
6.1: potassium permanganate; methyl tributylammonium chloride / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
6.2: 0 - 5 °C
With
potassium permanganate; N-Bromosuccinimide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl tributylammonium chloride;
dmap; dilauryl peroxide; palladium 10% on activated carbon;
In
tetrahydrofuran; tetrachloromethane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 0.17 h / 160 °C / microwave irradiation
2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr
3.1: dmap / tetrahydrofuran / 125 h / 20 °C
4.1: N-Bromosuccinimide / dilauryl peroxide / tetrachloromethane / 4.25 h / 60 °C / Inert atmosphere
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C / Inert atmosphere
6.1: potassium permanganate; methyl tributylammonium chloride / dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere
6.2: 0 - 5 °C
With
potassium permanganate; N-Bromosuccinimide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; methyl tributylammonium chloride;
dmap; dilauryl peroxide; palladium 10% on activated carbon;
In
tetrahydrofuran; tetrachloromethane; dichloromethane;
![tert-butyl 2,3-diphenylpyrido[2,3-b]pyrazine-5(6H)-carboxylate](/Databaselist/images/loading.webp)
