Technology Process of (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole
There total 6 articles about (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; t-butyldimethylsilyl amine; tin(IV) chloride;
In
tetrahydrofuran;
at 120 ℃;
for 1h;
optical yield given as %ee;
enantioselective reaction;
Microwave irradiation;
DOI:10.1021/ol101566h
- Guidance literature:
-
Multi-step reaction with 4 steps
2: trifluoroacetic acid; triethylsilane / 110 - 120 °C / Sealed vessel
3: potassium hexamethylsilazane / tetrahydrofuran / -78 - 0 °C
4: tin(IV) chloride; 4-methyl-morpholine; t-butyldimethylsilyl amine / tetrahydrofuran / 0.67 - 1 h / 120 °C / Microwavw irradiation
With
4-methyl-morpholine; triethylsilane; t-butyldimethylsilyl amine; tin(IV) chloride; potassium hexamethylsilazane; trifluoroacetic acid;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid; triethylsilane / 110 - 120 °C / Sealed vessel
2: potassium hexamethylsilazane / tetrahydrofuran / -78 - 0 °C
3: tin(IV) chloride; 4-methyl-morpholine; t-butyldimethylsilyl amine / tetrahydrofuran / 0.67 - 1 h / 120 °C / Microwavw irradiation
With
4-methyl-morpholine; triethylsilane; t-butyldimethylsilyl amine; tin(IV) chloride; potassium hexamethylsilazane; trifluoroacetic acid;
In
tetrahydrofuran;
